Extracellular DNA is essential for maintaining Bordetella biofilm integrity on abiotic surfaces and in the upper respiratory tract of mice.

Bacteria form complex and highly elaborate surface adherent communities known as biofilms which are held together by a self-produced extracellular matrix.We have previously shown that by adopting a biofilm mode of existence Pillowcases in vivo, the gram negative bacterial pathogens Bordetella bronchiseptica and Bordetella pertussis are able to effi

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Effects of the aurora kinase inhibitors AZD1152-HQPA and ZM447439 on growth arrest and polyploidy in acute myeloid leukemia cell lines and primary blasts

Background Aurora kinases play an essential role in the orchestration of chromosome separation and cytokinesis during mitosis.Small-molecule inhibition of the aurora kinases has been shown to result in inhibition of cell division, phosphorylation of histone H3 and the induction of apoptosis in a number of cell systems.These characteristics have led

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Correction of Breast Ptosis in Immediate Breast Reconstruction

Background:.Nipple-sparing mastectomy is psychologically advantageous and can result in superior cosmetic outcomes.However, nipple position adjustment is challenging, and ischemic complications may arise.For patients who require timely mastectomies and reconstructions, concurrent mastopexy may prevent nipple malposition and reduce the risk for futu

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